Formulated for those with mild to moderate acne, Differin Gel is the first prescription strength retinoid available over-the-counter to clear and prevent acne. It contains 0.1% adapalene, which was created for superior tolerability compared to other prescription retinoids and was the first FDA approved acne retinoid for consistently clear skin. It works to regulate skin cell turnover and acts as an anti-inflammatory agent to reduce acne and redness.